how does glp 1 increase insulin Mechanism of glucose-dependent, GLP1-potentiated secretion in GLP-1 and the kidney: from

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Only 10%15% of active GLP-1 reaches the general circulation intact, thus leading to minimal fasting plasma levels of 015 pmol/L [24]

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In the VTA, GLP-1R stimulation enhances AMPA/kainate-type glutamatergic input to dopaminergic neurons, modulating their excitability and reducing the salience of conditioned cues [5]

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