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doi: 10.1097/ADM.0000000000001110

Even if not every person with obesity should be on GLP-1 drugs, theres still a huge gap

The term GOP refers to a solution that contains a mixture of GLP-1, OXM, and peptide YY (PYY)

Gonadal steroids can also influence GLP-1R expression in the brain and other tissuesin the whole hypothalamus, for example, the highest GLP-1R expression is found in the late proestrus stage (46), providing further mechanistic support for potentially higher sensitivity to GLP-1 effects during this phase of the cycle (33, 47)

S.SiddiqiZ

The biological pathways remain active, but receptor stimulation is lower