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Semaglutide, the active ingredient in Wegovy, has been studied in clinical trials lasting up to 2 years, providing substantial evidence about its long-term tolerability

Glucagon-like peptide 1: an introduction and possible implications for neuropsychiatry

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Some patients experience mild side effects like nausea, digestive discomfort, or fatigue, which usually resolve over time

If your BMI is between 27 and 29, you may still qualify if you have weight-related health conditions such as high cholesterol, high blood sugar, or an A1C of 5.7 or higher

Clinical Evidence: Nausea Rates in Tirzepatide vs Semaglutide Studies In the SURPASS clinical trial program for tirzepatide, nausea occurred in approximately 25-33% of participants across all dosing phases, with most cases classified as mild to moderate and decreasing over time