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Similarly, mean changes in body weight were smaller: 5.3% (95% CI, 5.4% to 5.2%) for tirzepatide vs 3.3% (95% CI, 3.4% to 3.2%) for semaglutide at 3 months, 8.2% (95% CI, 8.4% to 8.0%) for tirzepatide vs 5.0% (95% CI, 5.1% to 4.8%) for semaglutide at 6 months, and 11.4% (95% CI, 12.0% to 10.8%) for tirzepatide vs 6.2% (95% CI, 6.7% to 5.8%) for semaglutide at 12 months

In the SGLT2i group, 101 participants were hospitalised (mean number of hospitalisations=2.7, median number of hospitalisations=2), with a mean and median length of stay of 2.4 and 2 days, respectively

These findings provide direct genetic evidence that variation in the drug target genes contributes to inter-person variability in response and lay the foundation for precision medicine approaches in the treatment of obesity

A washout period is a planned pause between stopping one medication and starting another

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