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The fat pads that give the cheeks, temples, and under-eye area their volume are among the first to diminish, because the skin there is thinner and has less structural support than body areas

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The following figure illustrates the drop in ferritin (and thus iron stores) after blood donation and quantifies the iron loss per unit: At Nervana Medical, we often see this pattern in men on testosterone therapy who undergo repeated phlebotomy and need iron treatment to battle their fatigue despite having optimized their testosterone