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Levodopa) Onset * Slow: develops over days to weeks Key Features (think: lead pipe rigidity) * Severe muscle rigidity * Hyperthermia (high fever) * Altered mental status (confusion coma) * Autonomic instability: * BP * HR * sweating Labs * Very high CK (creatine kinase) * Leukocytosis * Possible myoglobinuria risk of acute kidney injury Treatment * Stop offending drug immediately * Supportive care (ICU often needed) * Medications: * Dantrolene * Bromocriptine Serotonin Syndrome (SS) Cause Excess serotonin activity, often due to: * SSRIs (e.g

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