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Where the research should go next Key open questions include how much endogenous GLP1 increase is needed for sustained weight change, whether combinations of diet, prebiotics, probiotics and nutraceuticals can match injectable outcomes, and the longterm safety of such combinations

Nature (2003) 422(6928):1736

Sony Sherpa, (MBBS) - May 28, 2025 Fact Checked and Updated by Dr

While generally regarded as safe for short-term use in healthy individuals, the long-term safety of routine digestive enzyme supplementation in patients on GLP-1 therapy has not been systematically evaluated

Semaglutide Indications: : Ozempic an adjunct to diet and exercise to improve glucose control in adults with type 2 diabetes mellitus

Differential effects of GLP-1 receptor agonists on cancer risk in obesity: a nationwide analysis of 1.1 million patients