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In randomized clinical trials, tirzepatide has demonstrated mean weight reductions ranging from approximately 15% at the 5 mg maintenance dose to 20.9% at the 15 mg dose over 52 weeks [2]

Inflammatory cytokines in diabetic kidney disease: pathophysiologic and therapeutic implications

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In contrast to insulin, GLP-1 R agonists were associated with a lower risk of cardiovascular events such as myocardial infarction, cardiovascular death, and stroke

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The jury is still out, but there does seem to be some connectioneven drugmakers have acknowledged it
