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The observed clinical benefits appear to stem primarily from weight loss rather than direct analgesic mechanisms

J Am Coll Cardiol 69(8):841858

Coopman K, Wallis R, Robb G, Brown AJ, Wilkinson GF, Timms D, et al

Diabetes Obes Metab 25(1):5667 Rosenstock J, Wysham C, Frias JP et al (2021) Efficacy and safety of a novel dual GIP and GLP-1 receptor agonist tirzepatide in patients with type 2 diabetes (SURPASS-1): a double-blind, randomised, phase 3 trial

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