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Comparability studies are required when there are changes in the manufacturing process or formulation

In clinical trials, severe diarrhea was reported in one pediatric patient with FC treated with LINZESS 72 mcg once daily and in one pediatric patient with IBS-C treated with LINZESS at a dose higher than the recommended 145 mcg once daily dosage for IBS-C

It contains 0.9% benzyl alcohol as a preservative, which prevents bacterial growth after repeated withdrawals from the vial

Additionally, Semaglutide has been demonstrated to significantly decrease appetite by delaying gastric emptying and reducing intestinal motility

Hydration management Semaglutide slows gastric emptying