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We note that MR-Egger regression has lower statistical power compared to other methods (e.g., IVW) due to its reliance on the Instrument Strength Independent of Direct Effect (InSIDE) assumption and its sensitivity to weak instruments

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(accessed May 2013) 71.European Medicines Agency (EMA) Investigation into GLP-1-based diabetes therapies concluded

J Clin Med 11(13):3858 Koutroumpakis E, Kaur R, Taegtmeyer H, Deswal A (2021) Obesity and heart failure with preserved ejection fraction

However, some scholars have proposed that the effect of GLP-1 in the liver is indirectly mediated by multiple mechanisms, such as reducing fat absorption or inhibiting fat cells through acyl-CoA synthetase long chain family member 1 (ACSL1), CCAAT/enhancer binding protein (C/EBP), peroxisome proliferator-activated receptor- (PPAR), and sterol regulatory element binding protein-1c (SREBP-1c) pathways to achieve the purpose of reducing liver lipids [38]