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GLP-1 stands for Glucagon-Like Peptide-1 , a natural hormone your body makes to: Help regulate blood sugar Slow down stomach emptying (so you feel full longer) Signal satiety to your brain GLP-1 medications mimic this natural hormone but have a longer-lasting effect in your body

[DOI] [PubMed] [Google Scholar] 60.Gera A., Latif F., Borra V., Naz S., Mittal V., Ayoobkhan F.S., et al

These fluctuations could be linked to changes in insulin regulation, which affects brain chemistry

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2025 Europe PMC Efficacy and safety of retatrutide, a GIP, GLP-1, and glucagon receptor agonist, in people with type 2 diabetes and inadequate glycaemic control with diet and exercise (TRANSCEND-T2D-1): a double-blind, randomised, phase 3 trial