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Persistent exhaustion after 4 weeks may indicate undereating, poor sleep quality, or an underlying metabolic issue unrelated to the medication

doi: 10.4093/dmj.2021.0314
SEL-8, a nuclear protein required for LIN-12 and GLP-1 signaling in caenorhabditis elegans

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Supplementation of 15-30 mg of elemental zinc daily is commonly recommended during active weight loss, but should be balanced with copper intake (1-2 mg daily) because long-term zinc supplementation can deplete copper stores