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Pathophysiologically, excessive Gs signaling results in excess GH, leading to acromegaly

Enhanced Metabolic Function Beyond weight loss, GLP-1 medication improves insulin sensitivity and blood sugar control, making it particularly beneficial for patients with pre-diabetes or type 2 diabetes

Lancet 2008;372:12401250

Bariatric care has seen a lot of innovation in recent years, as the FDA has approved non-surgical solutions like the Spatz3, the first adjustable weight-loss balloon in the world

[3] [21] Improvements were also observed in other cardiometabolic markers, including triglycerides, fasting glucose, and waist circumference all independently associated with cardiovascular risk

Randomized trials examining efficacy of GLP-1 agonists for weight loss were not designed to capture these events2 due to small sample sizes and short follow-up