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Given the heterogeneity of the included evidencespanning case reports, pharmacovigilance analyses, and observational cohortsthis review is framed primarily as a signal-detection and evidence-mapping exercise rather than a causal-inference analysis

This process preserves the full molecular spectrum of saffron, including volatile compounds like safranal, which are often lost during conventional extraction methods.Its content is 10 times higher in safranal and 20 times more concentrated in crocins than standard extracts, enhancing the effects of saffron on emotional balance

For clinicians and patients, this is a moment of transition

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