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Another possibility, said Miras, was that a genetically predetermined set point for body weight had a broader range for some people than others, meaning their body did not resist efforts to deviate from this weight as strongly as for other people

Another study showed that acute administration of exenatide was associated with increased hepatic glucose uptake during an oral glucose tolerance test (OGTT) and a reduction in endogenous glucose production, reinforcing the hypothesis of a direct action of GLP-1 on the liver [12]

Off-Label and Adjacent Options Metformin , a common and inexpensive type 2 diabetes drug, is sometimes used off-label where weight is tied to insulin resistance, including in polycystic ovary syndrome (PCOS)

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