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Methods Study design Representatives of the companies Bristol-Myers Squibb, Novo Nordisk, Sanofi, Merck, Novartis, Boehringer Ingelheim and Takeda were contacted with the request to provide the event numbers of acute pancreatitis with the respective drug and non-incretin comparators as well as the corresponding number of patient-years of exposure (PYOs) for the approved GLP-1 receptor agonists exenatide twice daily, exenatide weekly, liraglutide and lixisenatide, as well as the DPP-4 inhibitors sitagliptin, saxagliptin, vildagliptin, alogliptin and linagliptin

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A diagnosis of prediabetes (Hgb A1C between 5.7% and 6.4%, or similar fasting glucose values) does not automatically disqualify you, but it highlights the importance of effective weight management

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The trade-off is usually simple

The combination of berberine and isoliquiritigenin synergistically improved adipose inflammation and obesity-induced insulin resistance
