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Pierre adds that overlapping medications can also contribute to constipation
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As nausea and vomiting are the most common side effects of all existing GLP-1 pharmacotherapies, the ability for GIP agonism to reduce GLP-1induced illness behaviors but retain (if not enhance) weight loss and glycemic control may offer a new era in the treatment of obesity and diabetes

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Loss of exercise consistency

However, when combined with insulin or sulfonylureas (in patients with diabetes), the risk of low blood sugar increases significantly, which can manifest as fatigue, weakness, and other symptoms
