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Clinical research suggests GLP-1 receptor agonists are safe for long-term weight management under medical supervision

374 Exendin-4 has also been shown to stimulate osteoblast activity and mitigate bone loss in an ovariectomized mouse model

Figure 3

In one study, liraglutide and semaglutide were reported to mitigate the development of plaque lesions by changing the inflammatory pathway in a mouse model of AS (124)
Multisite research, including research at UAB, shows that oral semaglutide is nearly as effective as the widely used injectable version for treating obesity, delivering about 13.7 percent average weight loss over 64 weeks

Recent preclinical evidence demonstrates that central GLP-1R activation can suppress systemic inflammation by inhibiting TLR-mediated TNF- release via neuronal GLP-1Rs
