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Description
SURMOUNT-1 subgroup data from 2,542 women showed tirzepatide produced ~23% body weight reduction in peri/postmenopausal women vs 3% on placebo

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In addition, activation of GLP-1R regulates mitochondrial over fission by the cAMP/PKA pathway while improving mitochondrial function in A-treated astrocytes and ameliorating pathological lesions in AD (Xie et al., 2021)
Weight loss was strategic, not existential

Patients whose BMI falls between 25 and 29.9 may still qualify if they have documented metabolic syndrome, sleep apnea, cardiovascular disease, or other obesity-related conditions

Retatrutide can produce side effects from all three receptor pathways (GLP-1, GIP, and glucagon)
