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Nat Med 29(9):23582365 Butler J, Shah SJ, Petrie MC, Borlaug BA, Abildstrm SZ, Davies MJ, Hovingh GK, Kitzman DW, Mller DV, Verma S et al (2024) Semaglutide versus placebo in people with obesity-related heart failure with preserved ejection fraction: a pooled analysis of the STEP-HFpEF and STEP-HFpEF DM randomised trials

In a cohort study of individuals with T2D and metabolic-associated fatty liver cirrhosis (459 GLP-1RA users), GLP-1RA therapy was associated with reduced risks of hepatic decompensation, portal hypertension, hepatocellular carcinoma, and liver transplantation (111)

2024;64(1):204211e4

At 40 weeks, retatrutide achieved up to 2.0% A1C reduction alongside significant weight loss, again with no plateau observed

This review delves into the present comprehension of GLP-1R signaling in immune cells and emphasizes the therapeutic potential of GLP-1RAs in treating autoimmune and autoinflammatory diseases