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Although weight loss likely plays a major role, emerging evidence suggests that anti-inflammatory and neuromodulatory mechanisms may also contribute

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As a mitochondrial-derived peptide, it activates AMPK pathways associated with improved glucose metabolism and metabolic flexibility

In parallel, cultured hepatocyte models (alpha mouse liver 12 [AML12] cells) with RAP1A knockdown or overexpression were used to assess cellular lipid accumulation, fatty acid oxidation, and mechanistic pathways

Less common but documented: pancreatitis, gallbladder disease, and acute kidney injury