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GLP-1RA and GIP/GLP-1RA, although structurally similar to endogenous incretins, are resistant to inactivation by DPP-4, which prolongs their effects (Figure 1)

[DOI] [PMC free article] [PubMed] [Google Scholar] 42.Abdillahi SM, Balvanovi S, Baumgarten M, Mrgelin M

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The research fueling these claims includes studies that found semaglutide users may face a significantly higher risk of developing NAION compared to patients using other medications

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