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Retatrutide administered once weekly subcutaneously for 12 weeks resulted in a dose-dependent placebo-adjusted weight loss of up to 8.96 kg in the highest dose group and a placebo-adjusted HbA1c reduction of up to 1.6% in a phase II trial in individuals with T2DM [125]

Wearables won't tell you the drug is working pharmacologically, but they reliably track the day-to-day changes that accompany it

In November 2023, the FDA granted approval for tirzepatide under the brand name Zepbound for chronic weight management in adults with obesity (BMI 30 kg/m) or overweight (BMI 27 kg/m) with at least one weight-related comorbidity, as an adjunct to a reduced-calorie diet and increased physical activity

Most weight loss product scams start with promises that are simply too good to be true

This underscores that weight loss pharmacology must be metabolically intelligent, not just calorically restrictive

There is no specific diet to follow, but eating in a certain way may help reduce side effects and make the medications more effective