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This vastly exceeded the 14.9% average weight loss with semaglutide 2.4 mg weekly in the STEP-1 trial

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Common side effects include nausea, vomiting, diarrhea, constipation, bloating, gas and stomach pain

For researchers who have experience switching from tirzepatide to retatrutide or other peptide transitions , similar principles apply

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Preliminary results from the SURPASS-J-mono study in Japanese patients with T2D who were either therapy nave or on an antidiabetic monotherapy showed a head-to-head comparison of a tirzepatide treatment compared to therapy with the GLP-1RA dulaglutide at a dose of 0.75 mg (54, 76)