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Aims/hypothesis Regulators worldwide are reviewing safety data on glucagon-like peptide-1 receptor agonists (GLP-1RA), following reports by the Icelandic Medicines Agency in July 2023 of suicidal ideation and self-injury (SIS) in individuals taking liraglutide and semaglutide

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In fact, the majority of patients showed stable weight or continued weight loss after their last documented GLP-1RA prescription in the participating health systems.Notably, LLM-enabled curation of clinical notes revealed that patients without weight regain were significantly more likely to have documented exercise counseling after their last prescription, suggesting that continued physical activity may play a role in sustaining weight loss after GLP-1RA discontinuation