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Hypothalamic dysfunction is a common finding in PWS and it has been implicated in several manifestations of this syndrome such as hyperphagia, temperature instability, high pain threshold, sleep disordered breathing, and multiple endocrine abnormalities

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Recent estimates suggest that around 1.6 million adults used GLP-1 weight-loss drugs between early 2024 and early 2025, while broader data indicates up to 1.5 million people are currently taking them at any one time1

Human data (from a meta-analysis of 894 participants) show fenugreek supplementation (0.5 g to 10 g daily over 4 weeks to 6 months) reduces fasting glucose, post-meal glucose, and HbA1c

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