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Recent work shows that there is a GLP-1-brain-immune pathway that controls inflammation across the body

Change history 01 June 2024 A Correction to this paper has been published: Abbreviations ADA: American Diabetes Association BMI: Body Mass Index CKD: Chronic kidney disease eGFR: Estimated glomerular filtration rate FPG: Fasting plasma glucose GLP-1RAs: Glucagon-like peptide-1 receptor agonists GRADE: Grading of Recommendations, Assessment, Development and Evaluation JBI: Joanna Briggs Institute LDL-C: Lipoprotein cholesterol MACE: Major Adverse Cardiovascular Events RCTs: Randomized controlled trials SGLT2is: Sodiumglucose transport protein 2 inhibitors SBP: Systolic blood pressure T2DM: Type 2 diabetes mellitus MD: Mean difference OR: Odds ratio References Ma C-X, Ma X-N, Guan C-H, Li Y-D, Mauricio D, Fu S-B

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Despite the rates of success, about 15% of people will not see clinically relevant weight loss

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