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Placebo-controlled trials are critical to demonstrate that the drug is effective and safe and not just better than nothing

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The meta-regression analysis suggested that the apparent protective association of GLP-1RAs may emerge relatively early in treatment, a finding consistent with randomized trials reporting improvements in walking capacity after short-term therapy

doi: 10.1016/j.exger.2017.12.005 184 SmithaJ

Reeves, G

For example, a 2023 study showed that in the next 3 hours after consuming carbs, there was a 65% increase in GLP-1 , which is considerably more than in the placebo group**