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After matching, patients who were not on GLP-1Ra were twice as likely to develop end-stage renal disease or dialysis dependence in 5 years after diagnosis compared to patients using GLP-1 agonists (OR 2.35, 95% CI 1.39,3.976)

J Neurosci (2011) 31:390413

Several forces will shape this trajectory: Patent Expiry and Pricing: Semaglutides Loss of Exclusivity Off-patent semaglutide will be a defining event in 2026 as it begins to come off patent in several countries

doi: 10.1016/j.tips.2012.03.014

For cocaine use disorder, an ongoing clinical trial is registered (NCT07227948), and there is also an ongoing trial for methamphetamine use disorder (NCT07204249)

The strategies are complementary: a thicket can buy time for the product hop to complete the market transition, and the product hop reduces the commercial value of any generic that eventually gets through the thicket