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For instance, the Contrave Obesity Research studies (COR-I, COR II, COR-BMOD, and COR diabetes) were performed over a 56-week period [64,65]

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Unlike semaglutide which solely activates GLP-1R (one of the three pivotal receptors regulating glucose homeostasis), tirzepatide also activates glucose-dependent insulinotropic polypeptide (GIP) receptor (GIPR) to enhance metabolic benefits with reduced side-effects 5

Although several recent preclinical studies using obese or diabetic models have demonstrated broadly consistent cardioprotective effects in line with CVOTs with GLP-1RAs, wider implementation of obesity/diabetes experimental models will be crucial to strengthen the translational link between preclinical mechanisms and clinical outcomes

Luong XG, Stevens SK, Jekle A et al (2020) Regulation of gene transcription by thyroid hormone receptor beta agonists in clinical development for the treatment of non-alcoholic steatohepatitis (NASH)

Additionally, evaluating how these therapies interact with current antidiabetic treatments and determining their suitability for combination therapies may further enhance their clinical value