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Filippatos TD, Panagiotopoulou TV, Elisaf MS

Recent FDA approvals and indications for products containing semaglutide include the reduction of cardiovascular risk in patients with type 2 diabetes and body weight reduction for obesity

In view of the steady market growth of GLP-1RA drugs and prospects of potential expansion to hugely profitable and self-selling indications such as weight management or Parkinsons disease [38], research is urgently needed to clarify the relationship between the use of GLP-1RA and mental health, as well as to identify individuals at a higher risk of suicidal ideation and self-injury

Researchers should assess receptor overlap and potential additive effects carefully before combining retatrutide with other GLP-1R, GIPR, or GCGR-active compounds

2013;369:145-154) found that intensive lifestyle intervention focused on weight loss did not reduce cardiovascular events in a large cohort of adults with overweight/obesity and type 2 diabetes