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At the 12mg dose, 11.2% of Retatrutide participants stopped treatment due to side effects compared to 7% for Semaglutide and 9.1% for Tirzepatide

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In contrast, exenatide appeared to worsen drinking outcomes in lean individuals, suggesting that body weight may influence treatment response

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[DOI] [PubMed] [Google Scholar] 5.Nauck MA, Heimesaat MM, Orskov C, Holst JJ, Ebert R, Creutzfeldt W

In clinical trials, the triple agonist (GLP-1 + GIP + glucagon) produced the highest weight loss ever recorded in a drug trial