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For patients, the practical effect is a clearer dose-escalation pathway: standard 2.4 mg, evaluate response over 1216 weeks, and consider 7.2 mg if response is below target without needing to switch molecule or mechanism

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Accordingly, restoration of nuclear SREBP-1c expression in liver-specific Chrebp defective mice normalized expression of some lipogenic genes, while not affecting glycolytic genes expressing

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