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B., and Kastin A

Clients who maintain structured weight lifting during GLP-1 therapy preserve significantly more muscle and metabolic rate giving them a much stronger foundation for maintaining weight loss after discontinuing the medication

While these drugs may prove largely safe in the short and long term, the attitude toward them as a quick weight-loss aid does seem to echo what drove the Fen-Phen craze in the 90s an all-too-quick willingness to take a drug that some say promises fast and easy weight loss without a critical look at the reality of that statement or the potential side effects

As demand surged, these drugs became in short supply beginning in 2022

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To investigate the relative contribution of non-genetic factors that predict GLP1 medication efficacy, we fit a linear model to assess the combined effect of age, sex, pre-treatment BMI, drug type, drug dose and time on drug on total BMI loss (Supplementary Table 3)