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Metabolic effects beyond weight loss Some blood pressure improvements appear before significant weight loss occurs, suggesting additional mechanisms such as: Improved endothelial (blood vessel lining) function Reduced sympathetic nervous system activity Better glucose and lipid regulation This indicates that tirzepatide may influence blood pressure through both weight-dependent and metabolic pathways

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Sulfonylureas: Another type of oral medication that stimulates the pancreas to release more insulin, helping to lower blood sugar levels

Tirzepatide is a glucagon-like peptide-1 (GLP-1) receptor agonist and glucose-dependent insulinotropic polypeptide (GIP) receptor agonist, which work together to improve blood sugar control and promote weight loss in patients with type 2 diabetes

Considering the use of GLP-1 receptor agonists in women with obesity prior to pregnancy: a narrative review

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