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Description
However, neither Trulicity nor Ozempic is approved for this use, unlike GLP-1 agonists such as Wegovy (semaglutide) and Mounjaro (tirzepatide), Administration: Both are administered once weekly by subcutaneous (under-the-skin) injection using an auto-injector pen

semaglutide, n =50

Appetite and Weight Changes : Because tirzepatide reduces appetite, some people may find that they lose weight without trying

Glucagon receptor activation introduces a distinct mechanism it increases energy expenditure through thermogenic signalling in adipose and hepatic tissue which operates independently of the appetite-regulating effects attributed to GLP-1R engagement

If this is to be the case, it brings into focus the issue of access to GLP-1RAs

PubMed CrossRef Wilding JPH, Batterham RL, Davies M, et al
