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Funding The author(s) declare that no financial support was received for the research and/or publication of this article

A standard curve for each qPCR assay was used for the quantification of target bacterial DNA in optimized amounts of fecal DNA samples

Collectively, these results highlight the role of vagal afferents in mediating the metabolic and appetite-regulating effects of peripheral GLP-1, thereby linking gut-derived signals to central regulatory circuits

Upon activation of adenosine monophosphate (AMP)-activated protein kinase (AMPK), berberine enhances insulin sensitivity, reduces hepatic glucose output, and has been shown in animal models to increase GLP-1 secretion, although this mechanism has not yet been confirmed in large human trials

Frequently Asked Questions Is berberine like Ozempic

GLP-1RAs significantly reduced endoplasmic reticulum (ER) stress-associated -cell death and recovered rat insulinoma cell line (INS-1) cells from ER stress-mediated translational repression in a PKA-dependent manner [34]