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In general terms, systematic reviews of limited evidence affirm that it seems that TNF superfamily and proinflammatory cytokines contribute to the neuroprogression of the disease [127]
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In our experience, these may include patient demographics (eg, age, sex, and ethnicity)
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Several case reports and small observational studies suggest that accidental exposure during early pregnancy has not produced clustered adverse outcomes, but sample sizes remain too small to establish definitive safety profiles
Off-label use of certain therapies, such as peptides, may be beneficial in managing metabolic syndrome, even if the patients BMI is not above 30
