weight loss drugs not glp 1 Understanding Medications: GLP-1 vs. Phentermine What Are the Side Effects

GLP-1 is a peptide secreted by L-type enteroendocrine cells in the ileum and colon in response to different nutrients, mainly glucose and lipids, whereas glucose-dependent insulinotropic polypeptide is produced by K cells present in the duodenum and the first portion of the jejunum

GLP-1 did not increase myocardial oxygen consumption or blood flow in humans or in swine, increasing p38-MAPK activity in lean, but not obese cardiac tissue [48]

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doi: 10.1111/dom.12076

While peripherally administered GLP-1 seemingly crosses the blood brain barrier (BBB) via simple diffusion, the half-life of GLP-1 is less than 2 min, leading to disagreement regarding whether peripherally derived GLP-1 is what activates CNS GLP-1R under physiological conditions

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