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Metformin does not directly stimulate insulin release and has been a first-line diabetes treatment for over 50 years

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335 In addition, Pluvicto (lutetium Lu 177 vipivotide tetraxetan, 177 Lu-PSMA-617) is also available for the treatment of adult patients with prostate-specific membrane antigen (PSMA)-positive metastatic castration-resistant prostate cancer (mCRPC), who have received prior androgen receptor (AR) inhibitor and paclitaxel-based chemotherapy, which was approved by the FDA in March 2022

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