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Effect on Anti-Inflammatory Cell Signalling and Cytokine Expression Five studies examined the beneficial effects of GLP-1RAs on macroscopic and microscopic changes in colitis [19,20,21,22,23] and six studies examined their effects on the reduction in proinflammatory cytokines [19,20,21,22,23,24]

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It plays a vital role in energy metabolism, DNA repair, and cellular signaling

Therefore, it was essential to extract information from MD simulation data to understand whether the binding of SR18 alters the signaling switches of GLP-1R compared to its reported ligand-free structure

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