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Both drug classes lower glucose concentrations (though through distinct mechanisms) without excess risk for hypoglycaemia, reduce body weight and albuminuria and prevent cardiovascular events, but they have opposing effects on glucagon secretion which is augmented by SGLT-2 inhibitors but suppressed by GLP-1 receptor agonists

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United States Pharmacopeia (USP) Pharmaceutical CompoundingSterile Preparations

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Combination Therapy: For patients with established cardiovascular disease AND obesity, combination therapy with both medications may provide optimal benefitsup to 1.8% additional A1C reduction and 25% weight loss