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The administration of the triple agonist resulted in the improvement of steatohepatitis in a dose-dependent fashion, with some female mice showing a complete resolution

Regarding lipotoxicity, a study in kidneys of mice fed a high-fat diet (55) revealed that the GLP-1 receptor agonist dulaglutide changed the lipid content of the organ, including reductions in diacylglycerols, phosphatidic acids, phosphatidylglycerols, and triglycerides

Effects of GLP-1 receptor activation on a pentylenetetrazolekindling rat model

10.1056/NEJMoa2413258 89 SawadaN.AdachiK.NakamuraN.MiyabeM.ItoM.KobayashiS.et al (2020)

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In contrast, the total H3 acetylation in the liver was significantly enhanced after NaB intervention in vivo, and the total H3 acetylation was also obviously enhanced in vitro in HepG2 cells after NaB treatment, independent of GPR43 or GPR109a