sglt2 inhibitors vs glp-1 vs. Agonists to Treat the Heart, the Kidneys and the Brain Recommendations for SGLT2i versus GLP-1

Tirzepatide enhances insulin secretion in a glucose-dependent manner, suppresses glucagon when glucose levels are elevated, and delays gastric emptying

Cognitive and behavioral problems might also manifest

Magnesium is one of the most practical supplements on a GLP-1 because it targets two of the most common complaints at once: constipation and disrupted sleep

Many patients posting on GLP-1 non-responder Reddit forums report diminishing motivation after months without results

doi: 10.1001/jama.2017.0562 [DOI] [PubMed] [Google Scholar] 65

It also means the initial side effect window falls on Friday night and Saturday, minimizing workday disruption