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Used tirzepatide vials, syringes, and needles should be disposed of in a dedicated sharps container to prevent injury or contamination

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3840 The phenotype observed after GLP-1R knockout (KO) includes various physiological and metabolic changes

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It is important to note that whilst injection site reactions are common, there is no evidence that upper-arm injections increase systemic adverse effects compared with other recommended sites

17 Therefore, when designing a dual agonist, either His or Tyr can be chosen for position 1 by weighing the required GLP-1 and GIP activity, and Phe is also worth considering