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In a T-cell-driven adoptive transfer (AdTr) colitis mouse model, liraglutide significantly improved disease activity markers, including histological activity in colonic tissue and the colon weight-to-length ratio, likely due to its ability to reduce CCL20, IL-33, and IL-22 [23]

However, cagrilinitide, exenatide, and orforglipron did not exhibit a significant increase in constipation risk

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A review of the FDA adverse event database revealed an increased incidence of thyroid cancer with exenatide whn compared with a control drug ( J Clin Endocrinol Metabolism