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Description
Wegovy received FDA approval as a weight loss drug in 2021
2015;32(10):e29-30

Important Safety Information for Ozempic (semaglutide) injection Warning: Risk of Thyroid C-Cell Tumors In studies with mice and rats, semaglutide (the active ingredient in Ozempic and Wegovy) caused thyroid tumors, including thyroid cancer

This is why, for so many patients with PsA and RA, biologics only work partially

Dose adjustments of insulin or insulin secretagogues are often necessary to prevent hypoglycemia when initiating semaglutide therapy

Additionally, sitagliptin has been shown to lower the proinsulin-to-insulin ratio (an indicator of -cell function) and increase the homeostasis model assessment-B index, a measure of insulin production (49, 50)