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This doesnt necessarily mean that HRT boosts semaglutides efficacy, the study authors proposed, but rather that not receiving HRT may weaken the post-menopausal bodys response to semaglutide

Whole-cell patch-clamp recordings of dorsal lateral septum neurons revealed that genetic Glp-1r ablation leads to increased excitability of these cells

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While there is no established direct effect of semaglutide on salivary gland function through its GLP-1 receptor mechanism, several indirect pathways may explain why some patients report dry mouth during treatment

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Diabetologia 60(8):13851389