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Patients should never increase their dose more rapidly than prescribed, even if they feel they are tolerating the current dose well
doi: 10.1152/ajpgi.1999.277.4.G829
This data included age, sex, BMI, muscle parameters, duration of diabetes, and comorbidities
Natriuretic Peptides as Biomarkers: Narrative Review and Considerations in Cardiovascular and Respiratory Dysfunctions
The difference is statistically significant but practically modest
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